Molecular Mechanisms of Protein Biosynthesis


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Published: June 01, received: February 01, Released: June 25, accepted: February 28, [Advance Publication] Released: - corrected: -. Article overview. References Related articles 0. Figures 0. Information related to the author. Supplementary material 0. Evans, D. Ageing Res. Kaeberlein, M. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.

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Smith, E. Quantitative evidence for conserved longevity pathways between divergent eukaryotic species.

Translation (biology)

Genome Res. McCormick, M.

A comprehensive analysis of replicative lifespan in 4, single-gene deletion strains uncovers conserved mechanisms of aging. Cell Metab. Hamilton, B. A systematic RNAi screen for longevity genes in C. Genes Dev. Pan, K.

Protein Synthesis (Translation) | Microbiology

Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell 6 , — Hansen, M. Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 6 , 95— Mehta, R.

Regulation of mRNA translation as a conserved mechanism of longevity control. Biol , 14—29 Planta, R. The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae. Yeast 14 , — Chiocchetti, A. Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span. Steffen, K.

Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. Kapahi, P. MacInnes, A. The role of the ribosome in the regulation of longevity and lifespan extension. Wiley Interdiscip. RNA 7 , — Jia, M. Global expression profiling of yeast treated with an inhibitor of amino acid biosynthesis, sulfometuron methyl. Genomics 3 , 83—92 Natarajan, K. Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast.

Cell Biol. Patil, C.

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Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein response. PLoS Biol. Harbison, C. Transcriptional regulatory code of a eukaryotic genome. Nature , 99— MacIsaac, K. An improved map of conserved regulatory sites for Saccharomyces cerevisiae. BMC Bioinformatics 7 , Foiani, M. GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae. Ribosomal protein L33 is required for ribosome biogenesis, subunit joining, and repression of GCN4 translation.

Delaney, J.

Mechanism of protein biosynthesis on ribosome studied by X-Ray crystallographic approaches.

Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. Aging Cell 12 , — Hinnebusch, A. Translational regulation of GCN4 and the general amino acid control of yeast.

Moy, T. Identification of a role for Saccharomyces cerevisiae Cgr1p in pre-rRNA processing and 60S ribosome subunit synthesis. Microbiology , — Brar, G. High-resolution view of the yeast meiotic program revealed by ribosome profiling. Ingolia, N. Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling. Wek, R. Coping with stress: eIF2 kinases and translational control. Bailey, T. Nucleic Acids Res. Fordyce, P. De novo identification and biophysical characterization of transcription-factor binding sites with microfluidic affinity analysis.

Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. Genome Biol. YeTFaSCo: a database of evaluated yeast transcription factor sequence specificities. Nucleic Acids Res 40 , D—79 Lieb, J. Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association. Promoter-specific binding of Rap1 revealed by genome-wide maps of protein—DNA association.

Hu, Z. Genetic reconstruction of a functional transcriptional regulatory network. Lickwar, C. Genome-wide protein-DNA binding dynamics suggest a molecular clutch for transcription factor function. Venters, B. A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces.

Cell 41 , — Joo, Y. Gcn4p-mediated transcriptional repression of ribosomal protein genes under amino-acid starvation.

EMBO J. Yang, R.

Molecular Mechanisms of Protein Biosynthesis Molecular Mechanisms of Protein Biosynthesis
Molecular Mechanisms of Protein Biosynthesis Molecular Mechanisms of Protein Biosynthesis
Molecular Mechanisms of Protein Biosynthesis Molecular Mechanisms of Protein Biosynthesis
Molecular Mechanisms of Protein Biosynthesis Molecular Mechanisms of Protein Biosynthesis
Molecular Mechanisms of Protein Biosynthesis Molecular Mechanisms of Protein Biosynthesis
Molecular Mechanisms of Protein Biosynthesis Molecular Mechanisms of Protein Biosynthesis

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